Prescription opioids are widely used in modern medicine, but they often cause confusion, especially when different medications contain similar ingredients. Oxycodone and Percocet are two names that frequently come up in conversations about pain relief, yet many people aren’t sure how they differ or if they’re the same drug.
This article will explore what oxycodone is, what Percocet contains, and how the two medications differ in terms of formulation, use, and risk. It will also examine the role each plays in pain management, their potential for misuse, and the importance of medical guidance when using opioid pain medication.

What Is Oxycodone and How Does It Work?
Oxycodone is a potent opioid analgesic commonly prescribed for managing pain severe enough to require opioid treatment. It works by binding to opioid receptors in the brain and spinal cord, altering pain perception. Oxycodone is available in several forms, including immediate-release and extended-release tablets. Extended-release versions, such as OxyContin, are designed for around-the-clock pain relief, especially in chronic pain scenarios.
As an opioid medication, oxycodone carries a high risk of misuse, dependence, and addiction. Its pain-relieving effects are powerful, making it one of the most commonly prescribed opioids for moderate to severe pain. However, due to its potency, oxycodone use must be closely monitored by a healthcare professional. The effects of oxycodone can vary depending on the dose and formulation, and misuse can lead to withdrawal symptoms and serious health consequences, including respiratory depression.
If you or a loved one is struggling with dependence on oxycodone or other opioid medications, explore our outpatient OxyContin addiction treatment program in New Jersey, which provides more than just detox. We provide structured support to ease withdrawal symptoms, reduce cravings, and develop effective relapse prevention plans. With flexible scheduling, treatment combines medication management and evidence-based therapy, allowing clients to maintain work, school, or family responsibilities.
What Is Percocet?
Percocet is a combination of oxycodone and acetaminophen. This medication contains both an opioid and a non-opioid analgesic. Acetaminophen enhances the pain-relieving effects of oxycodone by acting on different pain pathways in the body. Percocet is available in various dosages, such as those containing 10 mg of oxycodone and 325 mg of acetaminophen per tablet.
Because Percocet contains acetaminophen, it introduces additional considerations. While the combination improves pain relief, it also increases the risk of liver damage, particularly if the medication is taken in higher-than-prescribed doses or combined with other products that contain acetaminophen.
This risk underscores the importance of adhering to prescribed dosages and avoiding alcohol or other hepatotoxic substances while taking Percocet. If you or your loved one is struggling with Percocet addiction, make sure to visit our specialized program.
Key Differences Between Oxycodone and Percocet
The main distinction lies in composition. Oxycodone is a single active ingredient, whereas Percocet combines oxycodone with acetaminophen. This difference significantly impacts how each medication is used.
Percocet may be preferred for shorter durations of pain management where enhanced pain relief is needed without stepping up to higher opioid doses.
The presence of acetaminophen in Percocet introduces a ceiling effect, increasing the dose beyond a certain point does not significantly increase pain relief but does increase the risk of liver toxicity. In contrast, oxycodone alone can be titrated more flexibly under medical supervision.
Comparing oxycodone and Percocet also reveals differences in risk profiles: Percocet carries both opioid-related risks and the added potential for liver damage, while oxycodone alone is associated solely with opioid effects. For individuals struggling with dependency, Percocet addiction treatment programs offer specialized care to address both the physical and psychological components of addiction.
Risks, Misuse, and Dependence Potential
Both Percocet and oxycodone have a high potential for misuse, especially when used outside of a healthcare professional’s guidance. These opioid medications can lead to opioid use disorder, physical dependence, and withdrawal symptoms. The combination of oxycodone and acetaminophen does not reduce the risk of addiction. In fact, some may mistakenly believe that Percocet is safer due to the presence of a non-opioid component, which is not the case.
The Food and Drug Administration (FDA) and other health authorities classify these as controlled substances due to their potential for misuse and overdose. Opioid addiction can develop quickly, especially in individuals with a history of substance use or those taking the medication for longer periods. The risk of liver damage with Percocet further complicates its misuse, particularly if patients are unaware of other medications they are taking that also contain acetaminophen.

The Role of Each Medication in Pain Management
When choosing between oxycodone and Percocet, the decision often depends on the patient’s specific condition and medical history. Percocet is frequently prescribed for acute pain following surgery or injury, where short-term pain relief is needed, and the combination can enhance overall effectiveness. Oxycodone is used more often in situations where long-term opioid pain management is necessary, particularly when extended-release tablets are needed for chronic pain.
Medications that contain oxycodone, including Percocet and OxyContin, work by binding to opioid receptors in the brain and spinal cord. This mechanism effectively reduces the perception of pain but also carries significant risks. Given the range of prescription pain relievers available, many people are interested in how Percocet compares to other common options, such as hydrocodone, in terms of strength and effectiveness. For those considering their choices, understanding whether Percocet is stronger than hydrocodone can be an important part of making informed decisions about pain management. Healthcare professionals must evaluate the benefits and risks, considering factors like the risk of addiction, liver health, and the severity of pain.
Final Thoughts from New Chapter Recovery
At New Chapter Recovery, we understand the challenges of opioid dependence, whether from oxycodone, Percocet, or other prescription opioids. Our outpatient programs in New Jersey offer personalized treatment plans that combine medication management, evidence-based therapy, and relapse prevention, while allowing clients to maintain daily responsibilities.